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Enzyme Inhibitors
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2022
Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin Y-F et al.
. 2022.
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
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Cancer Cell. 40(9):939-956.e16.
News & Events
MIT PS-OC Mini-Symposium
May 30, 2017
Ludwig Center Oncology Seminar
May 8, 2017
Recent Publications
Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function.
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers.
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