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MIT/Mayo Physical Sciences Center for Drug Distribution and Drug Efficacy in Brain Tumors
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Antineoplastic Agents
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2018
Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL et al.
. 2018.
Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.
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Nat Commun. 9(1):4904.
2017
Gampa G, Vaidhyanathan S, Sarkaria JN, Elmquist WF
. 2017.
Drug delivery to melanoma brain metastases: Can current challenges lead to new opportunities?
Pharmacol Res. 123:10-25.
Laramy JK, Kim M, Gupta SK, Parrish KE, Zhang S, Bakken KK, Carlson BL, Mladek AC, Ma DJ, Sarkaria JN et al.
. 2017.
Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.
.
J Pharmacol Exp Ther. 363(2):136-147.
News & Events
MIT PS-OC Mini-Symposium
May 30, 2017
Ludwig Center Oncology Seminar
May 8, 2017
Recent Publications
Multimodal platform for assessing drug distribution and response in clinical trials.
Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer.
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
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