Title | Leveraging Immunopeptidomics To Study and Combat Infectious Disease. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Leddy OK, White FM, Bryson BD |
Journal | mSystems |
Volume | 6 |
Issue | 4 |
Pagination | e0031021 |
Date Published | 2021 Aug 31 |
ISSN | 2379-5077 |
Abstract | T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines. Peptides bound to MHCs can be identified at whole-proteome scale using mass spectrometry-a technique referred to as "immunopeptidomics." This technique has emerged as a powerful tool for identifying potential vaccine targets in the context of many infectious diseases. In this review, we discuss the contributions immunopeptidomic studies have made to understanding antigen presentation and T cell priming in the context of infection and the potential for immunopeptidomics to inform the development of vaccines to address pressing global health problems in infectious disease. |
DOI | 10.1128/mSystems.00310-21 |
Alternate Journal | mSystems |
PubMed ID | 34342538 |
PubMed Central ID | PMC8407116 |
Grant List | R01 AI022553 / AI / NIAID NIH HHS / United States R21DE026582 / / HHS | National Institutes of Health (NIH) / / / MIT Department of Biological Engineering / / / Ragon Institute of MGH, MIT and Harvard (Ragon Institute) / R21 DE026582 / DE / NIDCR NIH HHS / United States R01 AR073252 / AR / NIAMS NIH HHS / United States U54 CA210180 / CA / NCI NIH HHS / United States |