Leveraging Immunopeptidomics To Study and Combat Infectious Disease.

TitleLeveraging Immunopeptidomics To Study and Combat Infectious Disease.
Publication TypeJournal Article
Year of Publication2021
AuthorsLeddy OK, White FM, Bryson BD
Date Published2021 Aug 31

T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines. Peptides bound to MHCs can be identified at whole-proteome scale using mass spectrometry-a technique referred to as "immunopeptidomics." This technique has emerged as a powerful tool for identifying potential vaccine targets in the context of many infectious diseases. In this review, we discuss the contributions immunopeptidomic studies have made to understanding antigen presentation and T cell priming in the context of infection and the potential for immunopeptidomics to inform the development of vaccines to address pressing global health problems in infectious disease.

Alternate JournalmSystems
PubMed ID34342538
PubMed Central IDPMC8407116
Grant ListR01 AI022553 / AI / NIAID NIH HHS / United States
R21DE026582 / / HHS | National Institutes of Health (NIH) /
/ / MIT Department of Biological Engineering /
/ / Ragon Institute of MGH, MIT and Harvard (Ragon Institute) /
R21 DE026582 / DE / NIDCR NIH HHS / United States
R01 AR073252 / AR / NIAMS NIH HHS / United States
U54 CA210180 / CA / NCI NIH HHS / United States