|Leveraging Immunopeptidomics To Study and Combat Infectious Disease.
|Year of Publication
|Leddy OK, White FM, Bryson BD
|2021 Aug 31
T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines. Peptides bound to MHCs can be identified at whole-proteome scale using mass spectrometry-a technique referred to as "immunopeptidomics." This technique has emerged as a powerful tool for identifying potential vaccine targets in the context of many infectious diseases. In this review, we discuss the contributions immunopeptidomic studies have made to understanding antigen presentation and T cell priming in the context of infection and the potential for immunopeptidomics to inform the development of vaccines to address pressing global health problems in infectious disease.
|PubMed Central ID
|R01 AI022553 / AI / NIAID NIH HHS / United States
R21DE026582 / / HHS | National Institutes of Health (NIH) /
/ / MIT Department of Biological Engineering /
/ / Ragon Institute of MGH, MIT and Harvard (Ragon Institute) /
R21 DE026582 / DE / NIDCR NIH HHS / United States
R01 AR073252 / AR / NIAMS NIH HHS / United States
U54 CA210180 / CA / NCI NIH HHS / United States