Nhan L. Tran, Ph.D.

Nhan TranDr. Nhan L. Tran is a Professor in the Department of Research and Cancer Biology at Mayo Clinic Arizona. Dr. Tran’s research has been focused on determining the cellular and biochemical mechanisms of action of candidate genes expressed in highly invasive glioblastoma cells and their matrix of aberrant signaling to discover points of convergence that can serve as targets of vulnerability for therapeutic intervention. His laboratory focuses on the identification and characterization of certain members of the super family of cytokine receptors, the tumor necrosis factor receptors (TNFR) and their downstream signals via RhoGTPases to play important roles in modulating glioblastoma cell adhesion, invasion and cell survival. In addition, Dr. Tran’s expertise also lies in high-throughput assay development, and applying molecular chemical libraries screens to exploit novel GBM targets as an innovative strategies to treat invasive glioblastoma. In addition, his research also focuses in characterizing GBM intratumor heterogeneity and genomic aberration of invasive glioblastoma cells by implementing range of genomic technologies (whole genome, exome, RNA sequencing and methylation) to study therapeutic resistance and drug delivery.