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MIT/Mayo Physical Sciences Center for Drug Distribution and Drug Efficacy in Brain Tumors
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2018
Gampa G, Kim M, Cook-Rostie N, Laramy JK, Sarkaria JN, Paradiso L, DePalatis L, Elmquist WF
. 2018.
Brain Distribution of a Novel MEK Inhibitor E6201: Implications in the Treatment of Melanoma Brain Metastases.
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Drug Metab Dispos. 46(5):658-666.
Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL et al.
. 2018.
Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.
.
Nat Commun. 9(1):4904.
2017
Laramy JK, Kim M, Gupta SK, Parrish KE, Zhang S, Bakken KK, Carlson BL, Mladek AC, Ma DJ, Sarkaria JN et al.
. 2017.
Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma.
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J Pharmacol Exp Ther. 363(2):136-147.
News & Events
MIT PS-OC Mini-Symposium
May 30, 2017
Ludwig Center Oncology Seminar
May 8, 2017
Recent Publications
Identification of Src Family Kinases as Potential Therapeutic Targets for Chemotherapy-Resistant Triple Negative Breast Cancer.
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function.
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